Yes, every once in a while the planets align. Some questions to consider:

Is there a significant other contributing cash flow to the home budget?

Is there a nest egg? 401K or other instrument that can be cashed in if [and only if] all else fails?

Define startup? Is it bricks & mortar? High overhead environment? Require major up front investment?

I won't get out of bed in the morning without a Lean Canvas to guide my efforts. Have you complete this simple 9 step process? http://leancanvas.com

There are few challenges in life more rewarding than starting a new business from the ground up. But it takes an inner peace! {grin} And focus. Laser-like focus.

Put yourself in a position to win, even if a number of events go south. If you proceed, then commit 100%.