Not exactly sure what you mean. Typically you get an exit either because the company in which you invested is acquired or it goes public (there are other options, but those are the normal ones). Angel investors usually consider the acquisition potential when making an investment. If there are a lot of potential acquirers, that is better than if there are very few options. What is your specific situation and what do you want to know?

If you're structured as a C-corp (which, if you're going to raise venture capital, you should be), then it shouldn't matter. Most VCs have foreign LPs. If you're an S-corp, it can be a problem due to limitations around who can own shares. Also if you're doing government work, it could be a problem. Otherwise, I wouldn't worry about it.